Summary: The study evaluated the antibacterial efficacy of acetone and ethanol extracts from Tamarindus indica leaves against S. aureus and K. pneumoniae using disk diffusion and MIC assays. Both extracts showed significant antibacterial activity, with K. pneumoniae being more sensitive. The acetone extract exhibited lower MIC values (9.375 mg/mL) than ethanol (18.75 mg/mL). Results suggest that tamarind leaves contain bioactive compounds with therapeutic potential, supporting their traditional use. Further research is needed to isolate active constituents and assess mechanisms of action.