Rakesh Vishwarup, Shridhar N. Mathad, S. Nagaraju, Sandip V. Kamat, Deepak B. Shirgaonkar
1 Department of Physics, G.M University Davanagere, Karnataka, India.
2 Department of Engineering Physics, K. L. E Institute of Technology, Hubballi, 580027, Karnataka, India.
3 Department of Studies & Research in Biochemistry, Tumkur University, Tumkur, 572137, Karnataka, India.
4 PM Shri Kendriya Vidyalaya DIAT, Girinagar, Pune, 411025, India.
5 Department of Physics, Anandibai Raorane Arts, Commerce and Science College, Vaibhavwadi, 416810, Maharashtra, India.
*Author to whom correspondence should be addressed:
nagarajubiochem@gmail.com (Shridhar N. Mathad);
drdeepakshirgaonkar@gmail.com (Deepak B. Shirgaonkar)
ABSTRACT
Mg1-xZnxFe2O4, Mg1-xCoxFe2O4, and Mg1-xNixFe2O4 ferrites synthesized by using Co-precipitation method. The structural characterizations of these samples were carried out and the formation of single phase ferrite was substantiated through powder X-ray diffraction (XRD), which revealed single phase cubic spinel structure, with lattice constants ranging from 8.323 to 8.353 Å, 8.328 to 8.351 Å, and 8.315 to 8.366 Å for the Mg1-xZnxFe2O4, Mg1-xCoxFe2O4, and Mg1-xNixFe2O4 ferrites, respectively. Surface morphology was investigated through scanning electron microscopic (SEM) analysis. The grain sizes for the Mg1-xZnxFe2O4, Mg1-xCoxFe2O4, and Mg1-xNixFe2O4 ferrites were found to vary from 3.745 to 4.227 μm, 4.034 to 5.08 μm, and 3.946 to 4.887 μm, respectively. The prepared samples showed high anticoagulant properties for the highest concentration of dopant proved by re-calcification time (RT), prothrombin time (PT) and platelet aggregation measurements. The higher RT, PT and Activated partial thromboplastin time (aPPT) values for the x=0.35 ferrites and lower platelet aggregation of the x=0.35 ferrites reveal that the anticoagulant properties of the x=0.35 ferrites are superior to those of the x=0.15 and x=0.25 ferrites for all samples.
Significance of the study:
This study highlights the synthesis and characterization of Mg1-xZnxFe2O4, Mg1-xCoxFe2O4, and Mg1-xNixFe2O4 ferrites, showcasing their potential as anticoagulant agents. The research demonstrates that higher dopant concentrations (x=0.35) significantly enhance the anticoagulant properties, offering valuable insights for biomedical applications, particularly in developing advanced blood-coagulation inhibitors.
Summary of the study:
Mg1-xZnxFe2O4, Mg1-xCoxFe2O4, and Mg1-xNixFe2O4 ferrites were synthesized via co-precipitation and structurally characterized using XRD and SEM. The samples exhibited a single-phase cubic spinel structure with varying grain sizes. Anticoagulant properties were assessed, revealing superior performance for ferrites with x=0.35, evidenced by increased re-calcification, prothrombin, and activated partial thromboplastin times, along with reduced platelet aggregation.