Summary: The review examines the role of metal-based compounds in COVID-19 therapy. It outlines two strategies—drug repurposing and discovery approaches—for developing effective treatments against SARS-CoV-2. Highlighting the antiviral and immune-modulatory potential of metallodrugs, the study discusses their application as enzyme inhibitors and vaccine adjuvants. Despite challenges like toxicity and safety profiling, metal-based therapeutics hold promise for enhancing treatment efficacy. The review underscores the need for targeted drug development, synergistic therapies, and continued research to address long-term implications and future pandemics.